Palmitoyl‐CoA inhibits the mitochondrial inner membrane anion‐conducting channel

FEBS Letters

Murray, A.G.¹  Halle-Smith, S.C.¹  Selwyn, M.J.¹ 

[1] School of Biological Sciences, University of East Anglia, Norwich NR4 7TJ, England

关键词: Palmitoyl-CoA;    Mitochondrial inner membrane;    Thermogenesis;    Inner membrane anion-conducting channel;    Anion channel;    CoASH;    free coenzyme A;    FCCP;    carbonyl cyanide p-(trifluoromethoxy)phenylhydrazone;    IMAC;    mitochondrial inner membrane anion channel;   

DOI  :  10.1016/0014-5793(88)80305-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Palmitoyl-CoA is shown here to inhibit the pH-dependent anion-conducting channel (IMAC) in the inner membrane of rat liver mitochondria, with half-maximal inhibition at 2.4 μM. It has little effect on the transport of ribose, thiocyanate and glutamate. Palmitic acid and palmitoyl-carnitine stimulate the entry of all the above metabolises. CoASH and carnitine have no effect on chloride uniport. Palmitoyl-CoA and the IMAC may have a role in controlling thermogenesis in liver mitochrondria.

【 授权许可】

Unknown