Nerve growth factor induces rapid redistribution of F‐actin in PC12 cells

FEBS Letters

Paves, Heiti¹  Neuman, Toomas¹  Metsis, Madis¹  Saarma, Mart¹ 

[1] Laboratory of Molecular Genetics, Institute of Chemical Physics and Biophysics, Estonian Academy of Sciences, Akadeemia 23, 200026 Tallinn, Estonian SSR, USSR

关键词: Nerve growth factor;    F-Actin;    Methyltransferase;    Enzyme inhibitor;    Insulin;    (PC12 cell);   

DOI  :  10.1016/0014-5793(88)81250-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Nerve growth factor (NGF) induces the redistribution of F-actin in rat pheochromocytoma PC12 cells within 2–10 min, whereas epidermal growth factor (EGF) has no effect on microfilament organization. This redistribution of F-actin in PC12 cells is not protein synthesis dependent, but can be blocked by methyltransferase inhibitors.

【 授权许可】

Unknown