Acidic fibroblast growth factor stimulates opsin levels in retinal photoreceptor cells in vitro

FEBS Letters

Hicks, David¹  Courtois, Yves¹ 

[1] Unité de Recherches Gérontologiques, INSERM U118-CNRS UA630, 29, rue Wilhem, 75016 Paris, France

关键词: Photoreceptor;    Tissue culture;    Growth factor;    Opsin;    Monoclonal antibody;    (Bovine retina);   

DOI  :  10.1016/0014-5793(88)80141-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It is demonstrated that newborn rat retinal photoreceptor cells can differentiate in monolayer culture, and synthesize de novo photoreceptor-specific proteins such as opsin. When maintained in serum supplemented medium on a laminin substrate, these cells survive for up to 3 weeks. The addition of acidic fibroblast growth factor stimulates an increase in the levels of opsin of 5–10-fold control values, and prolongs cell survival by up to 6 days.

【 授权许可】

Unknown