Transforming growth factor β stimulates collagen and glycosaminoglycan biosynthesis in cultured rabbit articular chondrocytes

FEBS Letters

Galera, P.¹  Mauviel, A.¹  Pujol, J.-P.¹  Redini, F.¹  Loyau, G.¹ 

[1] Laboratoire de Biochimie du Tissu Conjonctif, Université de Caen, CHU Côte de Nacre, F-14040 Caen Cedex, France

关键词: Transforming growth factor β;    Collagen;    Glycosaminoglycan;    Extracellular matrix;    Articular chondrocyte;   

DOI  :  10.1016/0014-5793(88)81327-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of transforming growth factor β (TGF-β) on the production of matrix macromolecules was studied in cultures of rabbit articular chondrocytes. A 24 h exposure to TGF-β at concentrations of 0.1, 1 and 10 ng/ml markedly stimulated the synthesis of collagen and non-collagen protein. Similar increases of glycosaminoglycan production was observed in the same experimental conditions. The distribution of these newly synthesized macromolecules between cell layer and medium was not altered by treatment with TGF-β. The factor slightly enhanced the proliferation of chondrocytes in these experiments but its potent effect on matrix synthesis was independent of this growth stimulation. These results indicate that articular chondrocytes are target cells for TGF-β and suggest that this growth factor could play a role in the repair process of cartilage during osteoarticular diseases.

【 授权许可】

Unknown