Effect of amrinone on myocardial mitochondria function

FEBS Letters

Mattioli, G.²  Bobyleva-Guarriero, Valentina²  Cappello, C.¹  Muscatello, U.²  Mussini, Cristina² 

[1] Chair of Cardiology, University of Modena, Italy;Institute of General Pathology, University of Modena, Italy

关键词: Amrinone;    Cardiac mitochondria;    Glutamate dehydrogenase;   

DOI  :  10.1016/0014-5793(88)80470-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The effect of amrinone on cardiac mitochondria of guinea pig was studied. It was found that amrinone does not change the respiratory function of cardiac mitochondria in the presence of α-ketoglutarate, whereas it inhibits glutamate oxidation. It was also found that amrinone strongly inhibits the activity of glutamic dehydrogenase of both crude extract from sonicated heart mitochondria and of purified preparation from bovine liver. This inhibition may explain the effect of amrinone on the oxidation of glutamate in mitochondria. These results are discussed in view of the contradictory effects of amrinone on cardiac and other tissues.

【 授权许可】

Unknown