Relationship of promagainin to three other prohormones from the skin ofXenopus laevis: A different perspective

FEBS Letters

Hunt, Lois T.¹  Barker, Winona C.¹ 

[1] Protein Identification Resource, National Biomedical Research Foundation, Georgetown University Medical Center, Washington, DC 20007, USA

关键词: Promagainin;    Procaerulein;    Domain homology;    Exon shuffling;    Exon duplication;    (Xenopus laevis);   

DOI  :  10.1016/0014-5793(88)80443-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We observed a striking sequence similarity between precursors for promagainin and procaerulein type I (excluding the caerulein peptide region). Additional comparisons of the promagainin precursor with those of other procaeruleins, proxenopsin, and peptide-Gly-Leu-amide revealed that all possess one or more copies of a structurally similar spacer module, from which an amphiphilic spacer peptide is cleaved. Promagainin yields the magainins, spacer peptides with antimicrobial activity; we suggest other spacer peptides may have similar activity. We propose that the genes for the four kinds of hormones were derived from a common ancestral gene through gene and exon duplications and that the procaerulein and proxenopsin genes are mosaic genes in which the original 3′-ends were replaced by exon shuffling.

【 授权许可】

Unknown