Urodilatin (CDD/ANP‐95‐126) is not biologically inactivated by a peptidase from dog kidney cortex membranes in contrast to atrial natriuretic peptide/cardiodilatin (α‐hANP/CDD‐99‐126)

FEBS Letters

Gagelmann, Michael¹  Forssmann, Wolf-Georg¹  Hock, Dieter¹ 

[1] Institute of Anatomy and Cell Biology, University of Heidelberg, Im Neuenheimer Feld 307, D-6900 Heidelberg, FRG

关键词: Atrial natriuretic peptide;    Cardiodilatin;    Urodilatin;    Proteolysis;    Biological activity;    (Vascular smooth muscle;    Kidney membrane);   

DOI  :  10.1016/0014-5793(88)80436-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Atrial natriuretic peptide (CDD/ANP-99-126) is rapidly inactivated by a membrane preparation from dog kidney cortex. Inactivation occurs by cleavage of the ring structure in the position between Cys-105 and Phe-106. A unique proteolytic product separated by HPLC on reverse-phase column appears as a single peak which elutes prior the intact peptide. In contrast, CDD/ANP-95-126 (urodilatin) which is released from the kidney is not destroyed by proteolysis using an identical membrane preparation.

【 授权许可】

Unknown