期刊论文详细信息
FEBS Letters
Heat‐stable microtubule protein MAP‐1 binds to microtubules and induces microtubule assembly
Maccioni, Ricardo B.1  Rivas, Coralia I.1  Vera, Juan C.1 
[1] Department of Biochemistry, Biophysics and Genetics, University of Colorado Health Sciences Center, B-121, Denver, CO 80262, USA
关键词: Microtubule-associated protein;    Heat stability;    Affinity purification;    Microtubule assembly;   
DOI  :  10.1016/0014-5793(88)80408-3
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

The microtubule-associated proteins, MAP-1, MAP-2 and tau, have been purified from brain tissue via a new approach using a heating step directly on the homogenate, followed by selective adsorption on calmodulin-Sepharose affinity columns and gel-filtration chromatography. Our results indicate that these MAPs share common biochemical properties, including heat stability, calmodulin binding and promotion of tubulin assembly into microtubules.

【 授权许可】

Unknown   

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