Role of endopeptidase‐24.11 in the inactivation of atrial natriuretic peptide

FEBS Letters

Stephenson, Sally L.¹  Kenny, A.John¹ 

[1] MRC Membrane Peptidase Research Group, Department of Biochemistry, University of Leeds, Leeds LS2 9JT, England

关键词: Atrial natriuretic peptide;    Membrane peptidase;    Neuropeptide;    Endopeptidase-24.11;    ANF;    atrial natriuretic factor;    ANP;    atrial natriuretic peptide (1–28) the prefixes h and r indicating human and rat;    E-24.11;    endopeptidase-24.11 (EC 3.4.24.11);   

DOI  :  10.1016/0014-5793(88)80375-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The circulating form of atrial natriuretic factor is a 28-residue peptide containing a 17-residue disulphide-linked ring. It has important actions on the kidney, largely on its haemodynamics, and at other sites including the adrenal cortex and CNS. It has a short half-life in vivo and is rapidly inactivated when incubated with kidney microvillar membranes. Of the battery of peptidases present in that membrane, only one, endopeptidase-24.11, is responsible for initiating the attack, and this commences with hydrolysis of the Cys⁷-Phe⁸ bond within the ring. Hydrolysis at this and other points has been shown to inactivate the peptide and this information has pointed the way to the synthesis of resistant analogues.

【 授权许可】

Unknown