Redox loops and proton pumps

FEBS Letters

Malmström, Bo G.¹ 

[1] Department of Biochemistry and Biophysics, University of Göteborg and Chalmers University of Technology, S-412 96 Göteborg, Sweden

关键词: Cytochrome oxidase;    Cytochrome a;    Proton translocation;    Proton pump;    Redox loop;    Redox-linked;   

DOI  :  10.1016/0014-5793(88)80745-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In a Review-Hypothesis, Mitchell [(1987) FEBS Lett. 222, 235–245] has recently suggested possible molecular mechanisms for proton translocation by cytochrome oxidase. In describing these mechanisms, he extended his own concept of a redox loop in a manner expected to lead to confusion. He also stated that the term redox-linked proton pump implies an indirect coupling between electron transfer and proton translocation, and that this type of coupling is very difficult to test experimentally. Here it is argued that the original meaning of a redox loop should be maintained, and proper definitions of the terms redox-linked proton pump and direct or indirect coupling are formulated. In addition, it is reasoned that both types of coupling are amenable to experimental tests.

【 授权许可】

Unknown