Epidermal plasminogen activator inhibitor (PAI) is immunologically identical to placental‐type PAI‐2

FEBS Letters

Ohkuma, M.¹  Kon, S.¹  Hibino, T.¹  Åstedt, B.³  Izaki, S.¹  Thorsen, S.² 

[1] Department of Dermatology, Iwate Medical University School of Medicine, Morioka, Japan;Department of Clinical Chemistry, University of Copenhagen, Hvidovre Hospital, Hvidovre, Denmark;Research Laboratories of the Department of Gynecology and Obstetrics, University Hospital of Lund, Lund, Sweden

关键词: Placental-type plasminogen activator inhibitory-2;    Endothelial-type plasminogen activator inhibitor-1;    Urokinase;    Tissue-type plasminogen activator;    (Human epidermis);   

DOI  :  10.1016/0014-5793(88)80731-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Plasminogen activator inhibitor (PAI) purified from human epidermis [(1986) FEBS Lett. 408, 273–277] was immunologically identified as placental-type PAI-2. In both fibrinolytic and synthetic substrate assays inhibitory activity of epidermal PAI was neutralized by anti-PAI-2, but not by anti-endothelial type PAI-1. Immunoblotting technique confirmed that the purified epidermal PAI is reactive with anti-PAI-2, but not with anti-PAI-1. Consequently PAI in human epidermis was demonstrable by immunohistochemical technique.

【 授权许可】

Unknown