Autoantibodies to the core proteins of hnRNPs

FEBS Letters

Guialis, Apostolia¹  Sekeris, Constantine E.¹  Dangli, Amalia¹  Vretou, Evangelia¹ 

[1] Biological Research Center, The National Hellenic Research Foundation, 48 Vassileos Constantinou Avenue, Athens 11635, Greece

关键词: Autoantibody;    Core protein;    hnRNP;    Immunoblotting;   

DOI  :  10.1016/0014-5793(88)80714-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A novel autoantibody reacting with the core polypeptides of hnRNP particles has been detected in the serum of a patient with systemic lupus eythematosus (SLE) and Sjögren's syndrome manifestations. Immunoblot analysis, using either rat liver or HeLa nuclear extracts as the antigen source, demonstrated that the autoantibody interacts with a specific subgroup of the core polypeptides of hnRNP particles, namely A₂, B₁ and B₂, but not with A₁, C₁ and C₂.

【 授权许可】

Unknown