Physiological roles of animal succinate thiokinases Specific association of the guanine nucleotide‐linked enzyme with haem biosynthesis

FEBS Letters

Weitzman, P.D.J.¹  Jenkins, T.M.¹ 

[1] Department of Biochemistry, University of Bath, Bath BA2 7AY, England

关键词: Succinate thiokinase;    Guanine nucleotide;    Heme synthesis;    Porphyrin synthesis;    Porphyria;    Mitochondrial metabolism;   

DOI  :  10.1016/0014-5793(88)80629-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The discovery of two distinct succinate thiokinases in mammalian tissues, one (G-STK) specific for GDP/GTP and the other (A-STK) for ADP/ATP, poses the question of their differential metabolic roles. Evidence has suggested that the A-STK functions in the citric acid cycle in the direction of succinyl-CoA breakdown (and ATP formation) whereas one role of the G-STK appears to be the re-cycling of succinate to succinyl-CoA (at the expense of GTP) for the purpose of ketone body activation. A third metabolic participation of succinyl-CoA is in haem biosynthesis. This communication shows that in chemically induced hepatic porphyria, when the demand for succinyl-CoA is increased, it is the level of G-STK only which is elevated, that of A-STK being unaffected. The results implicate G-STK in the provision of succinyl-CoA for haem biosynthesis, a conclusion which is further supported by the observation of a high G-STK/A-STK ratio in bone marrow.

【 授权许可】

Unknown