High levels of protein carboxyl methyltransferase in well‐differentiated human endometrial carcinoma

FEBS Letters

Solomon, Roya²  Ben-Baruch, Gilad¹  Kloog, Yoel²  Menczer, Joseph¹ 

[1] Department of Obstetrics and Gynecology, The Chaim Sheba Medical Center, Tel Hashomer, Sackler School of Medicine, Tel Aviv 69978, Israel;Department of Biochemistry, The George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel

关键词: Endometrial carcinoma;    Differentiation;    Protein carboxyl methylation;    PCM;    protein carboxyl methyltransferase;    [3H]SAM;    S-[methyl-3H]adenosyl-L-methionine;   

DOI  :  10.1016/0014-5793(88)80015-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The levels of protein carboxyl methyltransferase, an enzyme that methylates free carboxyl groups of proteins, were determined in normal human proliferative and secretory endometrium and in poorly and well-differentiated endometrial carcinoma. Protein carboxyl methyltransferase activity was 67% higher in the well-differentiated carcinoma than in the normal tissues, while similar enzyme levels were observed in the two normal tissues and in the poorly differentiated carcinoma. The results suggest that in the well-differentiated tumor there is excessive protein methylation and offer a possible biochemical probe for distinguishing between the two types of tumor.

【 授权许可】

Unknown