Complementary addressed modification of double‐stranded DNA within a ternary complex

FEBS Letters

Podust, L.M.¹  Zarytova, V.F.¹  Fedorova, O.S.¹  Knorre, D.G.¹ 

[1] Institute of Bioorganic Chemistry, Siberian Division of the USSR Academy of Sciences, 630090 Novosibirsk, USSR

关键词: Complementary addressed alkylation;    dsDNA;    CIR;    p-(N-2-chloroethyl-N-methylamino)phenyl residue;    dsDNA;    double-stranded DNA;    ssDNA;    single-stranded DNA;    other abbreviations are in accordance with IUPAC IUB recommendations;   

DOI  :  10.1016/0014-5793(88)80014-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Double-stranded DNA containing a d(pG)₁₈·d(pC)₁₈ sequence was shown to be selectively alkylated in the vicinity of this fragment using the 5′-p-(N-2-chloroethyl-N-methylamino)benzylamide of deoxyribooligocytidylate, CIRCH₂NH(pdC) _n (n = 9, 15), in conditions favouring triple-stranded complex formation.

【 授权许可】

Unknown