Loss of inducible photorepair in a frog cell line hypersensitive to solar UV light

FEBS Letters

Chao, Chuck C.-K.²  Lin-Chao, Sue¹ 

[1] Program in Molecular Biology, University of Texas at Dallas, Richardson, TX 75083, USA;Department of Biochemistry, University of Texas Health Science Center, Dallas, TX 75235 USA

关键词: Repair regulation;    Hypersensitivity;    Photorepair;    Solar UV;   

DOI  :  10.1016/0014-5793(87)81145-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The induction of enzymatic photorepair (EPR) in ICR 2A frog cells and a derived mutant cell line DRP36 hypersensitive to solar UV was studied. Using clonogenic assays, when induced wild-type cells demonstrated an 8-fold increase of EPR the mutant cells displayed a near-background level of inducible EPR. The constitutive EPR in mutant cells, however, was the same as in wild-type cells. A mixed culture of ICR 2A and DRP36 cells showed an intermediate inducible EPR depending upon the cell ratio. Inducible EPR was also detected at the DNA level in wild-type cells, but not in mutant cells.

【 授权许可】

Unknown