Nucleosomal repeat length in active and inactive genes

FEBS Letters

Vidali, Giorgio¹  De Ambrosis, Alessandro¹  Bonassi, Stefano¹  Ferrari, Nicoletta¹ 

[1] Istituto Nazionale per la Ricerca sul Cancro, Viale Benedetto XV, 10, 16132 Genova, Italy

关键词: Nucleosomal spacing;    Chromatin structure;    Transcription;    β-DR;    β-chain of the DR I class II histocompatibility antigen;   

DOI  :  10.1016/0014-5793(87)81142-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Nucleosomal repeat lengths of total chromatin, H4 histone and β-DR genes have been measured in logarithmically growing HeLa cells. We have detected significant differences in nucleosomal spacing between inactive chromatin and chromatin regions actively engaged in transcription. These differences are also maintained in metaphase chromosomes at times when transcription ceases although a shortening in nucleosomal repeat length is observed in active and inactive chromatin. These observations support a model where DNA-core histone interactions are temporarily altered to allow selective remodelling of chromatin organization.

【 授权许可】

Unknown