On the role of microsomal aldehyde dehydrogenase in metabolism of aldehydic products of lipid peroxidation

FEBS Letters

Pirozhkov, Sergej V.¹  Panchenko, Leonid F.¹  Antonenkov, Vasily D.¹ 

[1] All- Union Research Center for Medico-Biological Problems of Narcology, Kropotkinsky per. 23, Moscow 119034, USSR

关键词: Aldehyde dehydrogenase;    4-Hydroxyalk-2-enal;    Detoxication;    Lipid peroxidation;   

DOI  :  10.1016/0014-5793(87)80484-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To elucidate a possible role of membrane-bound aldehyde dehydrogenase in the detoxication of aldehydic products of lipd peroxidation, the substrate specificity of the highly purified microsomal enzyme was investigated. The aldehyde dehydrogenase was active with different aliphatic aldehydes including 4-hydroxyalkenals, but did not react with malonic dialdehyde. When Fe/ADP-ascorbate-induced lipid peroxidation of arachidonic acid was carried out in an in vitro system, the formation of products which react with microsomal aldehyde dehydrogenase was observed parallel with malonic dialdehyde accumulation.

【 授权许可】

Unknown