期刊论文详细信息
FEBS Letters | |
Haloperidol‐succinylglycyl[125I]iodotyrosine, a novel iodinated ligand for dopamine D2 receptors | |
Delaage, M.1  Gehelmann, F.1  Girault, J.M.1  Labouesse, J.1  Garrigues, A.M.1  | |
[1] IBCN-CNRS, 1 rue Camille Saint-Saëns, 33077 Bordeaux Cedex and Immunotech, Lumigny, 13288 Marseille Cedex 9, France | |
关键词: Dopamine D2 receptor; Radioiodinated ligand; (Striatum); | |
DOI : 10.1016/0014-5793(87)80467-2 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
A novel radioiodinated ligand of the butyrophenone type has been synthesized for the quantification and characterization of dopamine D2 receptors. This haloperidol-derived ligand, haloperidol-succinylglycyl-[125I]iodotyrosine ([125I]HSGTI), binds rapidly (equilibrium is reached within 30 min, at 10 pM and 37°C) and with high affinity (K d=0.3 nM) to bovine striatal membranes. Its pharmacology, determined by competitive displacement with dopaminergic and non-dopaminergic drugs, is characteristic of binding to dopamine D2 receptors.
【 授权许可】
Unknown
【 预 览 】
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