Voltage‐dependent and multi‐state ionic channels induced by trichorzianines, anti‐fungal peptides related to alamethicin

FEBS Letters

Molle, G.¹  Duclohier, H.¹  Spach, G.¹ 

[1] Polymères, Biopolymères et Membranes, UA 500 CNRS, Faculté des Sciences de Rouen, BP 118, 76134 Mont Saint Aignan Cedex, France

关键词: Amphipathic peptide;    Peptaibol;    Planar lipid bilayer;    Membrane conductance;    Voltage-dependent channel;    Peptide aggregation;   

DOI  :  10.1016/0014-5793(87)80449-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The ionophore properties of two peptaibols of the trichorzianine family have been investigated in planar lipid bilayers and compared to those of alamethicin. Macroscopic conductance experiments reveal voltage-dependent channels only in the thinnest membranes and a greater efficiency of the neutral analog. In single-channel experiments, a multi-state behaviour, consistent with the usual barrel-stave model, is disclosed but the discrete current fluctuations are much more rapid than for alamethicin. The results indicate a stringent requirement for the helix length/bilayer thickness match in agreement with a previous model and suggest the design of new synthetic peptides.

【 授权许可】

Unknown