The preparation and properties of novel reversible polymer‐protein conjugates 2‐ω‐Methoxypolyethylene (5000) glycoxymethylene‐3‐methylmaleyl conjugates of plasminogen activators

FEBS Letters

Barret Kalindjian, S.¹  Garman, Andrew J.¹ 

[1] Biosciences Research Centre, Beecham Pharmaceuticals Research Division, Yew Tree Bottom Road, Epsom KT18 5XQ, England

关键词: Urokinase;    Plasminogen activator;    Chemical modification;   

DOI  :  10.1016/0014-5793(87)80319-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The preparation of a reagent capable of reversibly attaching polyethylene glycol to proteins and the use of this material in modifying the plasminogen activators urokinase- and tissue-type plasminogen activator are described. The characterisation and the reversible nature of these protein-polymer conjugates are discussed, and some of the in vitro properties of these modified enzymes are explored.

【 授权许可】

Unknown