FEBS Letters | |
The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria | |
Ivanovien·e, L.1  Kholodenko, B.1  Toleikis, A.1  Z̆ilinskie·e, V.1  Borutait·e, V.1  Pras̆kevic̆ius, A.1  | |
[1] Research Institute for Technology and Safety of Drugs, 23 Kirov St, Kupavna, 142450 Moscow region, USSR | |
关键词: Adenine nucleotide translocator; Oxidative phosphorylation; Mitochondrion; Control coefficient; (Heart); | |
DOI : 10.1016/0014-5793(87)80298-3 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The regulative role of adenine nucleotide translocators (ANTs) in oxidative phosphorylation has been estimated by the titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the presence of a non-rate limiting creatine phosphokinase ADP-regenerating system. It has been established that the respiration rate is not controlled by ANTs in the two extreme states, state 3 and state 4. On the other hand, at an intermediate respiration rate (30–70% of the state 3 respiration, which roughly corresponds to that under physiological conditions) the ANT control coefficient had a value of 0.62–0.75. Thus, ANTs seem to play a key role in the regulation of oxidative phosphorylation.
【 授权许可】
Unknown
【 预 览 】
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