The role of adenine nucleotide translocators in regulation of oxidative phosphorylation in heart mitochondria

FEBS Letters

Ivanovien·e, L.¹  Kholodenko, B.¹  Toleikis, A.¹  Z̆ilinskie·e, V.¹  Borutait·e, V.¹  Pras̆kevic̆ius, A.¹ 

[1] Research Institute for Technology and Safety of Drugs, 23 Kirov St, Kupavna, 142450 Moscow region, USSR

关键词: Adenine nucleotide translocator;    Oxidative phosphorylation;    Mitochondrion;    Control coefficient;    (Heart);   

DOI  :  10.1016/0014-5793(87)80298-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The regulative role of adenine nucleotide translocators (ANTs) in oxidative phosphorylation has been estimated by the titration of respiration of isolated rabbit heart mitochondria with carboxyatractyloside in the presence of a non-rate limiting creatine phosphokinase ADP-regenerating system. It has been established that the respiration rate is not controlled by ANTs in the two extreme states, state 3 and state 4. On the other hand, at an intermediate respiration rate (30–70% of the state 3 respiration, which roughly corresponds to that under physiological conditions) the ANT control coefficient had a value of 0.62–0.75. Thus, ANTs seem to play a key role in the regulation of oxidative phosphorylation.

【 授权许可】

Unknown