FEBS Letters | |
Sequence conservation in the 3′‐untranslated regions of neurone‐specific enolase, lymphokine and protooncogene mRNAs | |
Day, I.N.M.1  Moore, D.C.McN.1  Allsopp, M.T.E.P.1  Thompson, R.J.1  | |
[1] Department of Clinical Biochemistry, School of Clinical Medicine, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QR, England | |
关键词: Neurone-specific enolase; cDNA sequence; Sequence conservation; | |
DOI : 10.1016/0014-5793(87)80207-7 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
The C-terminal protein-coding and the entire 3′-untranslated regions of a cDNA corresponding to human neurone-specific enolase mRNA have been sequenced. The 3′-untranslated region is 892 bases long and shows a high degree of homology with the 3′-untranslated region of rat neurone-specific enolase mRNA. This sequence conservation is not seen in non-neuronal enolase mRNAs. Features of the conserved sequence include an A-rich region approx. 250 bases from the stop codon at a point corresponding to the polyadenylation signal site in non-neuronal enolase mRNA, and a repeating ATTT sequence. This unusual motif in eukaryotic mRNAs has previously been reported in the 3′-untranslated regions of lymphokine and protooncogene mRNAs.
【 授权许可】
Unknown
【 预 览 】
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