Effects of platelet‐activating factor on conversion of angiotensin I to II

FEBS Letters

Yasuda, Hisakazu¹  Kawaguchi, Hideaki¹ 

[1] Department of Cardiovascular Medicine, Hokkaido University, School of Medicine, Sapporo 060 Japan

关键词: Platelet-activating factor;    Angiotensin converting enzyme;    (Pulmonary endothelial cell);   

DOI  :  10.1016/0014-5793(87)80945-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

We have studied the effects of platelet-activating factor (alkyl-acetyl-GPC) on conversion of angiotensin I to II. Platelet-activating factor (PAF) had a novel effect on angiotensin I conversion. Pulmonary artery endothelial cells converted 30% of [¹²⁵I]angiotensin I to angiotensin II in the absence of PAF, but their activity was greatly stimulated in its presence. When PAF was added to pulmonary artery endothelial cells, the conversion of angiotensin I to II was enhanced up to 68%. Maximal stimulation without cellular damage was achieved at 10⁻⁵ M PAF. LysoPAF did not stimulate the conversion of angiotensin I to angiotensin II at any concentration used.

【 授权许可】

Unknown