α‐Actinin and spectrin have common structural domains

FEBS Letters

Wasenius, Veli-Matti²  Närvänen, Outi¹  Saraste, Matti³  Lehto, Veli-Pekka¹ 

[1] Departments of Pathology, University of Helsinki, 00290 Helsinki, Finland;Departments of Oncology, University of Helsinki, 00290 Helsinki, Finland;Departments of Medical Chemistry, University of Helsinki, 00290 Helsinki, Finland

关键词: Spectrin;    α-Actinin;    Sequence homology;    Actin binding;   

DOI  :  10.1016/0014-5793(87)80354-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The α- and β-subunits of spectrin are made of repeated homologous units of 106 residues. In the recently reported partial sequence of the chicken non-muscle α-actinin, a repetitive sequence homologous to the internal repeat in spectrin occurs several times. Both spectrin and α-actinin are components of the cytoskeletal network, the integrity of which is based on multiple and complex interactions. We suggest that the shared domain structure indicates common structural principles or interactions of spectrin and α-actinin and reflects their common evolution.

【 授权许可】

Unknown