Volatile anesthetics depress the depolarization‐induced cytoplasmic calcium rise in PC 12 cells

FEBS Letters

Tas, Piet W.L.²  Koschel, Klaus²  Kress, Hans G.¹  Eckhardt-Wallasch, Heike¹ 

[1] Institute of Anesthesiology, University Hospital, Josef-Schneider-Straβe 2 University of Würzburg, D-8700 Würzburg, FRG;Institute for Virology and Immunobiology, Versbacher Straβe 7, University of Würzburg, D-8700 Würzburg, FRG

关键词: Volatile anesthetic;    cytoplasmic free Ca2+;    Fura-2;    Ca2+ channel;    (PC 12 cell;    Rat);   

DOI  :  10.1016/0014-5793(87)80346-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

In the rat pheochromocytoma cell line PC 12, the effects of four volatile anesthetics (halothane, isoflurane, enflurane, methoxyflurane) on the K⁺-evoked intracellular calcium ([Ca²⁺]_i) rise were investigated using the Ca²⁺-sensitive fluorescence dye fura-2. The [Ca²⁺]_i rise was depressed, at clinical concentrations, by all anesthetics with almost identical aqueous IC₅₀ values. The study extends to neuronal cells the observation made previously in cardiac tissue that volatile anesthetics may interfere with Ca²⁺ fluxes through voltage-gated channels.

【 授权许可】

Unknown