Ile‐Ser‐bradykinin (T‐kinin) and Met‐Ile‐Ser‐bradykinin (Met‐T‐kinin) are released from T‐kininogen by an acid proteinase of granulomatous tissues in rats

FEBS Letters

Uehara, Soichiro²  Gotoh, Katsuhiro²  Sakamoto, Wataru¹  Satoh, Fumihiko³ 

[1] Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo 060, Japan;Tonan Hospital, Hokkaido University, Sapporo 060, Japan;Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060, Japan

关键词: T-Kinin;    Met-T-kinin;    Acid proteinase;    (Rat granulomatous tissue);    HPLC;    high-performance liquid chromatography;   

DOI  :  10.1016/0014-5793(87)80267-3

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

An acid proteinase of granulomatous tissues in rats with carrageenin-induced inflammation released kinin from T-kininogen. The kinin isolated by n-butanol extraction was separated by reverse-phase high-performance liquid chromatography into T-kinin and a T-kinin derivative. From determination of its amino acid composition and its immunoreactivity toward anti-bradykinin antiserum, the T-kinin derivative was identified as Met-Ile-Ser-bradykinin (Met-T-kinin).

【 授权许可】

Unknown