期刊论文详细信息
FEBS Letters | |
Ciguatoxin and brevetoxins share a common receptor site on the neuronal voltage‐dependent Na+ channel | |
Lazdunski, Michel1  Lombet, Alain1  Bidard, Jean-Noël1  | |
[1] Centre de Biochimie du CNRS, Parc Valrose,06034 Nice Cedex, France | |
关键词: Ciguatoxin; Na channel; Ciguatera; Brevetoxin; Receptor; Pyrethroid; AS2; Anemonia sulcata toxin 2; [3H]BTX-B; [3H]batrachotoxinin A 20-α-benzoate; CgTx; ciguatoxin; PbTx; brevetoxin (Ptychodiscus brevis toxin); TTX; tetrodotoxin; | |
DOI : 10.1016/0014-5793(87)80252-1 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Binding studies indicate that ciguatoxin and brevetoxin allosterically enhance in a very similar way the binding of [3H]batrachotoxinin A 20-α-benzoate to the neuronal Na+ channel protein. Moreovr ciguatoxin competitively inhibits the binding of [3H]brevetoxin-3 to rat brain membranes. The affinity of ciguatoxin for the Na+ channel is at least 20–50-times higher than that of brevetoxin. These results indicate that ciguatoxin and brevetoxins act at the same binding site on the sodium channel.
【 授权许可】
Unknown
【 预 览 】
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