Calcium involvement in mediating the action of octopamine and hypertrehalosemic peptides on insect haemocytes

FEBS Letters

Viswanatha, T.¹  Jahagirdar, A.P.¹  Milton, G.¹  Downer, R.G.H.¹ 

[1] Department of Biology, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada

关键词: Octopamine;    Hypertrehalosemic peptide;    Ca2+;    (Insect;    Hemocyte);   

DOI  :  10.1016/0014-5793(87)81195-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Octopamine, the hypertrehalosemic peptides HT-I and HT-II and the calcium ionophore A23187 elevate intracellular calcium levels in cultured haemocytes of Malacosoma disstria (Lepidoptera: Lasiocampidae). The octopamine-mediated response is dose-dependent and the magnitude of the response is influenced by the concentration of calcium in the incubation medium. Mianserin, an inhibitor of octopamine-mediated elevation of cyclic AMP production, blocks the octopamine-mediated increase in intracellular calcium but has no effect on the HT-I- and HT-II-mediated responses. The results indicate that some effects of octopamine are mediated through agonist-dependent calcium gating whereas others are expressed through receptors coupled to adenylate cyclase. The study also confirms previous suggestions that HT-I and HT-II elevate intracellular calcium concentrations.

【 授权许可】

Unknown