The processing and secretion of rat serum albumin by oocytes from Xenopus laevis

FEBS Letters

Foreman, R.C.²  Judah, J.D.¹ 

[1] Department of Experimental Pathology, School of Medicine, University College London, University Street, London WC1E 6JJ, England;Department of Pharmaceutical Chemistry, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX UK

关键词: Proalbumin processing;    Oocyte;    Albumin secretion;    mRNA;    (Xenopus laevis;    Rat liver);   

DOI  :  10.1016/0014-5793(87)81193-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Microinjection of rat liver mRNA into Xenopus oocytes led to the synthesis of intracellular proalbumin and the secretion of mature albumin into the incubation medium. The ionophore monensin abolished the secretion of albumin but not the processing of the precursor. A variety of protease inhibitors were added to the incubation medium but there was no detectable inhibition of proalbumin cleavage.

【 授权许可】

Unknown