Inositol 1,4,5‐trisphosphate and 5′‐GTP induce calcium release from different intracellular pools

FEBS Letters

Piiper, Albrecht¹  Söling, Hans-Dieter¹  Henne, Volkmar¹ 

[1] Abteilung Klin. Biochemie, Universität Göttingen, Robert-Koch-Str. 40, D-3400 Göttingen, FRG

关键词: Ca2+ release;    GTP;    Inositol 1;    4;    5-trisphosphate;    Endoplasmic reticulum;    (Parotid);   

DOI  :  10.1016/0014-5793(87)81037-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

It has been shown recently by several groups that 5′-GTP can release calcium from intracellular compartments independently from inositol 1,4,5-trisphosphate (Ins(1,4,5)P₃) by a mechanism which seems to be different from that used by Ins(1,4,5)P₃. We report here for the first time that the 5′-GTP-sensitive and the Ins(1,4,5)P₃-sensitive calcium pools reside in different intracellular compartments.

【 授权许可】

Unknown