Hormonal regulation of 6‐phosphofructo‐2‐kinase/fructose‐2,6‐bisphosphatase: Kinetic models

FEBS Letters

Goldstein, B.N.¹  Ivanova, A.N.² 

[1] >Institute of Biological Physics, USSR Academy of Sciences, Pushchino, Moscow Region, USSR;Institute of Chemical, Physics, USSR Academy of Sciences, Chernogolovka, Moscow Region, USSR

关键词: Bifunctional enzyme;    Graph-theoretical method;    Glucagon switching signal;    Critical phenomenon;    E1;    6-phosphofructo-2-kinase;    E2;    fructose-2;    6-bisphosphatase;    S1;    fructose 6-phosphate;    S2;    fructose 2;    6-bisphosphate;    F1;    cAMP-dependent protein kinase;    F2;    phosphoprotein phosphatase;   

DOI  :  10.1016/0014-5793(87)80665-8

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A graphical method to reveal the so-called ‘critical fragments’ in schemes of biochemical systems is considered. These fragments produce multiple steady states or self-oscillations in systems. As an example, the bifunctional enzyme, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase, regulated by glucagon through enzyme phosphorylation, is discussed. It is shown that this enzyme may act as a metabolic switching mechanism in discontinuous or oscillatory regimes, depending on the specific structure of its kinetic scheme. The boundaries of concentrational and parameter domains for these critical phenomena are also predicted.

【 授权许可】

Unknown