Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin

FEBS Letters

Troschka, Monika¹  Bialojan, Corinna¹  Caspar Rüegg, J.¹  Takai, Akira¹ 

[1] II. Physiologisches Institut, Universität Heidelberg, Im Neuenheimer Feld 326, 6900 Heidelberg, FRG

关键词: Okadaic acid;    Myosin dephosphorylation;    Muscle contractility;    (Skinned fiber);   

DOI  :  10.1016/0014-5793(87)81247-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Smooth muscle contraction depends on the state of myosin phosphorylation and hence on the balance of myosin light chain kinase and phosphatase activity. Effects of okadaic acid isolated from black sponge on both enzyme activities and contractility were studied in chemically skinned fibers from guinea pig taenia coli. The toxin strongly inhibits myosin phosphatase and enhances tension development.

【 授权许可】

Unknown