期刊论文详细信息
FEBS Letters | |
Molecular cloning and sequence analysis of cDNA coding for the precursor of the human cysteine proteinase inhibitor cystatin C | |
Lundwall, Åke1  Abrahamson, Magnus1  Grubb, Anders1  Olafsson, Isleifur1  | |
[1] Department of Clinical Chemistry, University of Lund, Malmö General Hospital, S-214 01 Malmö, Sweden | |
关键词: Cerebral hemorrhage; Cystatin C; Cysteine proteinase; Enzyme inhibitor; cDNA cloning; Nucleotide sequence; | |
DOI : 10.1016/0014-5793(87)80695-6 | |
学科分类:生物化学/生物物理 | |
来源: John Wiley & Sons Ltd. | |
【 摘 要 】
Recombinant cystatin C producing clones were isolated from a human placenta λgt11 cDNA library. The cDNA insert of one of the clones, containing 777 base pairs, encodes the complete mature cystatin C (120 amino acids) and a hydrophobic leader sequence of 26 amino acids, indicating an extracellular function of the inhibitor. The deduced protein sequence confirms the protein sequence of cystatin C isolated from human urine, but differs in one position from the sequence of the cystatin C fragment deposited as amyloid in hereditary cerebral hemorrhage with amyloidosis.
【 授权许可】
Unknown
【 预 览 】
Files | Size | Format | View |
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RO201912020289278ZK.pdf | 435KB | download |