Patterns of gene expression during plasmacytoid differentiation of chronic lymphocytic leukaemia cells

FEBS Letters

Leber, B.¹  Yaxley, J.C.¹  Norton, J.D.¹ 

[1] Department of Haematology, Royal Free Hospital School of Medicine, Pond Street, Hampstead, London NW3 2QG, England

关键词: Chronic lymphocytic leukaemia;    Differentiation;    Oncogene expression;   

DOI  :  10.1016/0014-5793(87)80126-6

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Chronic lymphocytic leukaemia (CLL) cells may be induced to undergo plasmacytoid differentiation in vitro in response to 12-O-tetradecanoyl phorbol acetate (TPA). We show here that plasmacytoid differentiation and the accompanying accumulation of Cμ immunoglobulin mRNA are preceded by a rapid transient increase in the expression of the proto-oncogenes, c-myc and c-fos. In terminally differentiated cells the level of c-fos mRNA returned to the original basal level whilst c-myc expression remained appreciably higher than in undifferentiated CLL cells. These data support a possible role for c-fos and c-myc in the programmed chain of events that occur during terminal differentiation of B-lymphocytes.

【 授权许可】

Unknown