Molecular cloning of human prostate specific antigen cDNA

FEBS Letters

Lundwall, Åke¹  Lilja, Hans¹ 

[1] Department of Clinical Chemistry, University of Lund, Malmö General Hospital, S-214 01 Malmö, Sweden

关键词: cDNA clone;    cDNA library;    Kallikrein-like;    (Human prostate);   

DOI  :  10.1016/0014-5793(87)80078-9

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A λgt11 clone encoding prostate specific antigen has been isolated from a human prostate cDNA library. The cDNA insert of 1415 nucleotides hybridizes specifically to a prostate mRNA species of 1.5 kb. The nucleotide sequence codes for part of a signal peptide, a short propiece and the mature protein of 237 amino acid residues. The M _r for the non-glycosylated protein was 26 089. One potential site for N-linked carbohydrate attachment was identified. The primary structure shows extensive homology with proteases of the kallikrein family.

【 授权许可】

Unknown