The L‐form of N‐7‐mercaptoheptanoyl‐O‐phosphothreonine is the enantiomer active as component B in methyl‐CoM reduction to methane

FEBS Letters

Pfaltz, A.¹  Thauer, R.K.²  Kobelt, A.¹  Ankel-Fuchs, D.² 

[1] Laboratorium für Organische Chemie, Eidgenössische Technische Hochschule, Universitätsstr. 16, CH-8092 Zürich, Switzerland;Fachbereich Biologie-Mikrobiologie, Philipps-Universität, Karl-von-Frisch-Straße, D-3550 Marburg, FRG

关键词: Methanogenic bacteria;    Methyl-CoM reductase;    Component B;    7-Mercaptoheptanoylthreonine phosphate;   

DOI  :  10.1016/0014-5793(87)80067-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The reduction of methyl-CoM to methane in methanogenic bacteria is dependent on a low-M _r, heat-stable compound designated component B, the structure of which has recently been assigned as N-7-mercaptoheptanoyl-O-phosphothreonine. We report here that only the enantiomer derived from O-phospho-L-threonine has cofactor activity. N-7-Mercaptoheptanoyl-O-phospho-D-threonine was neither active nor inhibitory.

【 授权许可】

Unknown