期刊论文详细信息
FEBS Letters
De novo CDP‐choline‐dependent glycerophosphorylcholine synthesis and its involvement as an intermediate in phosphatidylcholine synthesis
Infante, J.P.1 
[1] Division of Nutritional Sciences, Martha Van Rensselaer Hall, Cornell University, Ithaca, NY 14853, USA
关键词: Glycerophosphorylcholine;    Phosphatidylcholine;    CDP-choline;    Phosphatidylethanolamine;    (Muscle);    PC;    phosphatidylcholine;    PE;    phosphatidylethanolamine;    PG;    phosphatidylglycerol;    PI;    phosphatidylinositol;    PS;    phosphatidylserine;    G3P;    sn-glycerol-3-phosphate;    GPC;    sn-glycerol-3-phosphorylcholine;    C22:6n—3;    all-cis-4;    7;    10;    13;    16;    19-docosahexaenoate;   
DOI  :  10.1016/0014-5793(87)80031-5
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

The activity of CDP-choline-dependent glycerophosphorylcholine synthetase (CDP-choline:sn-3-glycerophosphate cholinetransferase), a newly discovered enzyme involved in the recently proposed pathways of acyl-specific phosphatidylcholine synthesis, is reported in rat liver. Endogenous CDP-choline, synthesized via the CMP-driven back reaction of phosphorylcholine transferase, is also shown to be a choline donor for this glycerophosphorylcholine synthetase. The function of glycerophosphorylcholine as an intermediate in phosphatidylcholine synthesis is demonstrated by specific isotope trapping whereby unlabelled glycerophosphorylcholine inhibited label incorporation from sn-[14C]glycerol-3-phosphate into phosphatidylcholine in mouse gastrocnemius, a tissue that is essentially devoid of the cytidine pathway for phosphatidylcholine synthesis and uses a non-allelic glycerophosphorylcholine synthetase (exogenous PC:sn-3-glycerophosphate cholinetransferase) in the synthesis of glycerophosphorylcholine.

【 授权许可】

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