Expression of a truncated v‐myb product in transformed chicken embryo fibroblasts

FEBS Letters

Baluda, Marcel¹  Soret, Johann²  Crochet, Janine²  Perbal, Bernard²  Kryceve-Martinerie, Cécile² 

[1] Department of Pathology, UCLA School of Medicine, Los Angeles, CA 90024, USA;Institut Curie, Section de Biologie, 91405 Orsay, France

关键词: Transformation;    Myeloblastosis;    V-myb oncogene;    Fibroblast;    (Avian);   

DOI  :  10.1016/0014-5793(87)80017-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Transformed cells have been isolated after transfection of chicken embryo fibroblasts (CEF) with the DNA of a recombinant clone (KXA 3457) in which the v-myb sequences are flanked by the two AMV-LTRs. Abnormal myb-specific RNA species and myb-related polypeptides were found to be expressed in these cells, suggesting that transformation of CEF by v-myb might require alterations of the oncogene product.

【 授权许可】

Unknown