期刊论文详细信息
FEBS Letters
Calcium‐binding proteins in rat skin
Heizmann, Claus W.1  Didierjean, Liliane2  Schelling, Claude P.1  Takagi, Takashi3  Rizk, Marthe4  Pavlovitch, Jana H.4 
[1] Institute of Pharmacology and Biochemistry, University of Zürich-Irchel, Winterthurerstrasse 190, CH-8057 Zürich Switzerland;Hôpital Cantonal Universitaire, CH-1211 Geneva, Switzerland;Tohoku University, Sendai 980, Japan;Hôpital des Enfants-Malades, F-75743 Paris Cedex 15, France
关键词: Ca2+-binding protein;    Parvalbumin;    (Skin;    Epidermis);    pI;    isoelectric point;    HPLC;    high performance liquid chromatography;    1D/2D PAGE;    one-dimensional/two-dimensional polyacrylamide gel electrophoresis;    PAP;    peroxidase anti-peroxidase;    PMSF;    phenylmethylsulfonyl fluoride;   
DOI  :  10.1016/0014-5793(87)80006-6
学科分类:生物化学/生物物理
来源: John Wiley & Sons Ltd.
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【 摘 要 】

Skin Ca2+-binding protein (SCaBP) was reported to be distinct from the Ca2+-binding parvalbumin (PV), however, more recently its amino acid sequence was shown to be identical to PV. We purified a protein (M r 12 000; pI4.5) from isolated epidermis (free of other cell layers) of adult rats and whole skin (containing no PV) of newborn rats. This protein is referred to as epidermal protein (EP-12), distinct from PV in its hydrophobicity, amino acid composition and immunological properties. Previously isolated SCaBP was shown to be a mixture of EP-12 and PV. The localization and possible functions of EP-12 and of PV in skin of adult and newborn rat are discussed.

【 授权许可】

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