ncreased 25‐hydroxyvitamin D levels in portal blood following cholecystokinin injection in the dog

FEBS Letters

Alon, R.²  Meyer, M.S.¹  Shibolet, S.¹ 

[1] Departments of Internal Medicine D, Ichilov Hospital, Tel-Aviv University, Sackler School of Medicine, 6 Weizmann Street, Tel-Aviv, Israel;Departments of Internal Surgery A, Ichilov Hospital, Tel-Aviv University, Sackler School of Medicine, 6 Weizmann Street, Tel-Aviv, Israel

关键词: Vitamin D;    Enterohepatic circulation;   

DOI  :  10.1016/0014-5793(87)81572-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

To establish whether an enterohepatic circulation of the metabolites of vitamin D exists, polyethylene catheters were cannulated into the portal vein of dogs. The dogs were then starved for 24 h and injected with cholecystokinin (CCK) to induce gall bladder contraction. At various time intervals thereafter blood samples were collected from the portal and the saphena veins, and sera prepared and analyzed for the metabolites of vitamin D. The serum levels of 25-hydroxyvitamin D [25(OH)D] were found to be significantly higher in the portal blood when compared with levels in peripheral blood following CCK injection. Since portal blood collects nutrients absorbed from the gut and as the dogs were starved for 24 h prior to blood collection, the only source of the increased concentrations of 25(OH)D in portal blood is likely to be bile. These findings support the notion that an enterohepatic circulation of 25(OH)D does exist under normal physiological conditions.

【 授权许可】

Unknown