Origins of stereospecificity in DNA damage by anti‐benzo[a]pyrene diol‐epoxides

FEBS Letters

Neidle, Stephen¹  Pearl, Laurence H.¹ 

[1] Cancer Research Campaign Biomolecular Structure Unit, Institute of Cancer Research, Sutton SM2 5PX, England

关键词: DNA damage;    Benzo[a]pyrene;    Intercalation;    DNA;    Molecular modelling Single-strand cleavage mechanism bl];   

DOI  :  10.1016/0014-5793(86)81126-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A general computational procedure for the modelling of intercalated DNA-ligand complexes has been developed, and is used here to model intercalated complexes of the (+)-anti and (-)-anti enantiomers of benzo[a]pyrene diol-epoxide (BPDE) with cytosine-3',5'-guanosine double-stranded DNA sequences (dCpG). Results are presented indicating differences between the behaviours of the two enantiomers which have implications for the understanding of the stereospecificity of DNA strand breakage by benzo[a]pyrene diol-epoxides.

【 授权许可】

Unknown