Identification of two toxins from scorpion (Leiurus quinquestriatus) venom which block distinct classes of calcium‐activated potassium channel

FEBS Letters

Castle, Neil A.¹  Strong, Peter N.¹ 

[1] MRC Receptor Mechanisms Research Group, Department of Pharmacology, University College London, Gower Street, London WC1E6BT, England

关键词: (Leiurus quinquestriatus) Apamin Charybdotoxin Ca2+ activation K + channel;   

DOI  :  10.1016/0014-5793(86)81095-X

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Two polypeptide toxins from scorpion (Leiurus quinquestriatus) venom which block distinct classes of calcium-activated potassium channels have been identified and partially purified. One toxin, at 50–100 , blocks apamin-sensitive potassium fluxes in hepatocytes and inhibits [¹²⁵I]monoiodoapamin binding. The other, more basic, toxin blocks apamin-insensitive potassium fluxes in erythrocytes at 200 and, to our knowledge, is the first toxin shown to block the erythrocyte calcium-activated potassium channel with high affinity. The possible co-identity of this latter toxin with charybdotoxin is discussed.

【 授权许可】

Unknown