Propylthiouracil, a selective inhibitor of NADH‐cytochrome b 5 reductase

FEBS Letters

Lee, Eibai¹  Kariya, Kimio¹ 

[1] Department of Pharmacology, Faculty of Pharmaceutical Sciences, Kobe-Gakuin University, Ikawadani-cho, Nishi-ku, Kobe 673, Japan

关键词: Propylthiouracil Enzyme inhibition NADH-cytochrome b 5reductase Cytochrome b 5Microsome;   

DOI  :  10.1016/0014-5793(86)81082-1

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Propylthiouracil inhibited the activity of NADH-cytochrome b ₅ reductase of rat liver microsomes using potassium ferricyanide as electron acceptor. On the other hand, NADPH-cytochrome P-450 reductase activity was not affected by the compound. NADH-supported reduction of cytochrome b ₅ was also inhibited by Propylthiouracil in the reconstituted system consisting of cytochrome b ₅ and partially purified NADH-cytochrome b ₅ reductase.

【 授权许可】

Unknown