The glycine‐rich loop of adenylate kinase forms a giant anion hole

FEBS Letters

Dreusicke, Dirk¹  Schulz, Georg E.¹ 

[1] Institut für Organische Chemie und Biochemie der Universität, Albertstr. 21, 7800 Freiburg i.Br. FRG

关键词: Adenylate kinase X-ray diffraction Structural homology Nucleotide-binding protein Oncogene;   

DOI  :  10.1016/0014-5793(86)81037-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The conformation of the glycine-rich loop of adenylate kinase is described in detail. It forms a giant anion hole for a sulfate ion, which presumably mimicks a nucleotide phosphoryl group. This loop had been called flexible, because at pH values of 6 or below it is displaced in the crystal. In the region of this loop the adenylate kinases are probably homologous to the p21 proteins. Is is known that a mutation in this loop at residue 12 of p21 causes cell transformation and therefore cancer. Other potentially homologous proteins are indicated.

【 授权许可】

Unknown