Chronic exercise training alters kinetic properties of rat skeletal muscle and myocardial lactate dehydrogenase

FEBS Letters

Lardy, Henry A.¹  Stratman, Frederick W.¹  Ji, Li L.¹ 

[1] Institute for Enzyme Research, University of Wisconsin-Madison, Madison, WI 53706, USA

关键词: Exercise training Lactate dehydrogenase Kinetic property Isoenzyme (Skeletal muscle Myocardium);   

DOI  :  10.1016/0014-5793(86)81036-5

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

10 weeks of treadmill running dramatically altered the kinetic properties of lactate dehydrogenase (EC 1.1.1.27) in skeletal muscle and myocardium in the rat. These changes, including V _max, K _m and optimal concentrations for pymvate and lactate, indicate that exercise training induces the formation of H-isozyme in skeletal muscle and M-isozyme in the heart and represent metabolic adaptations of these tissues to chronic aerobic exercise.

【 授权许可】

Unknown