A sequence homology between the pX genes of HTLV‐I/II and the murine IL‐3 gene

FEBS Letters

Shimotohno, Kunitada¹  Inoue, Tadashi²  Aota, Shin-ichi²  Gojobori, Takashi² 

[1] NationalCancer Center Research Institute, Tsukiji, Chuo-ku, Tokyo 104, Japan;National Institute of Genetics, Mishima, Shizuoka-ken 411, Japan

关键词: HTLV-I HLTV-II pX gene x-lor gene Interleukin 3 Sequence homology Leukemogenesis Oncogene;   

DOI  :  10.1016/0014-5793(86)81023-7

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Searching the protein sequence database for amino acid sequences homologous to the x-lor sequence in the pX region of human T-cell leukemia virus types I and II (HTLV-I/II), we found that there is a region of 38 amino acids where the murine interleukin 3 (IL-3) sequence has a 40% homology with the x-lor sequence. A statistical analysis shows that this homology is highly significant with a probability of 1.57 × 10⁻¹⁰. The biological implication of this homology is discussed.

【 授权许可】

Unknown