cDNA sequence of human β‐preprotachykinin, the common precursor to substance P and neurokinin A

FEBS Letters

Curtis, A.³  Going, J.¹  Fink, G.³  Rosie, R.³  Armstrong, A.³  Edwards, C.R.W.²  Harmar, A.J.³  Pascall, J.C.³  Chapman, K.³ 

[1] University Department of Pathology, Medical Buildings, Teviot Place, Edinburgh EH8 9AG, Scotland;University Department of Medicine, Western General Hospital, Edinburgh EH4 2XU, Scotland;MRC Brain Metabolism Unit, Royal Edinburgh Hospital, Morningside Park, Edinburgh EH10 5HF, Scotland

关键词: Substance P Substance K Neuropeptide K Tachykinin mRNA Carcinoid tumour;    cDNA;    complementary DNA;    mRNA;    messenger RNA;    NkA;    neurokinin A (formerly known as substance K;    neuromedin L or neurokinin α);    NpK;    neuropeptide K;    PPT;    preprotachykinin;    SP;    substance P;   

DOI  :  10.1016/0014-5793(86)81534-4

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

The nucleotide sequence of cDNA encoding the human substance P precursor, β-preprotachykinin (β-PPT), has been determined. The source of mRNA was a human laryngeal carcinoid tumour that contained a high concentration of immunoreactive substance P. The human β-PPT polypeptide is 129 amino acids long and contains regions encoding substance P and neurokinin A, each flanked by basic amino acid residues. Residues 72–107 of the human β-PPT polypeptide encode the sequence of neuropeptide K, an N-terminally extended form of neurokinin A recently isolated from porcine brain.

【 授权许可】

Unknown