A novel member of the serpin superfamily is encoded on a circular plasmid‐like DNA species isolated from rabbit cells

FEBS Letters

McFadden, G.²  Carrell, R.W.¹  Upton, C.² 

[1] Haematology Department, Addenbrooke's Hospital, Hills Road, Cambridge CB2 2QQ, England;>Department of Biochemistry, University of Alberta, Edmonton, Alberta, T6G 2H7 Canada

关键词: Shope fibroma virus;    Poxvirus;    spc DNA;    Serpin;    Serine protease inhibitor;   

DOI  :  10.1016/0014-5793(86)80023-0

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

A novel member of the serpin family of serine protease inhibitors is presented. A plasmid-like DNA was isolated from rabbit cells by its homology to the genome of Shope fibroma virus (SFV), a tumorigenic poxvirus of rabbits, and was shown elsewhere to encode a serpin-like protein [(1986) Mol. Cell. Biol. 6, 265-276]. Although significant DNA homology exists between the rabbit plasmid serpin open reading frame and the SFV terminal inverted repeat DNA there is no intact serpin counterpart encoded by this region of the SFV genome. The alignment of the novel plasmid-borne polypeptide with the serpin family of proteins confirms its status within this group.

【 授权许可】

Unknown