Uncharged tRNA error damping model

FEBS Letters

Gallant, Jonathan A.¹ 

[1] Department of Genetics SK-50, University of Washington, Seattle, WA 98195, USA

关键词: Translational accuracy;    uncharged tRNA;    Ribosome;   

DOI  :  10.1016/0014-5793(86)80977-2

学科分类：生物化学/生物物理

来源: John Wiley & Sons Ltd.

【 摘 要 】

Uncharged tRNA is known to bind to the ribosome in a codon-specific fashion. In this way, cognate uncharged tRNA competes with non-cognate aminoacyl-tRNA. If uncharged tRNA can be aminoacylated while on the ribosome, this will damp errors due to aminoacyl-tRNA imbalance. Kinetic analysis shows that this scheme reduces errors at ‘hungry’ codons considerably more effectively than J. Ninio's accuracy tuner model; for example, a 10-fold decrease in cognate aminoacyl-tRNA elicits only a 10% increase in the error frequency.

【 授权许可】

Unknown